Media Summary: Review of the regulatory networks that can be inferred by ChIP-seq assays on DNA--binding transcription factors. Different approaches to scaffolding contigs, including mate pairs, optical maps and 3C technologies Brief overview of the different levels of physical organization of the genome, from the linear DNA sequence to A/B compartments.
Mcb 182 Lecture 4 1 Forward Genetics - Detailed Analysis & Overview
Review of the regulatory networks that can be inferred by ChIP-seq assays on DNA--binding transcription factors. Different approaches to scaffolding contigs, including mate pairs, optical maps and 3C technologies Brief overview of the different levels of physical organization of the genome, from the linear DNA sequence to A/B compartments. Introduction to the two-sided Fisher's exact test as a method for performing genome-wide association studies (GWAS) on binary ... Introduction to the chromatin conformation capture assays, including 3C and 4C. A brief introduction into the concept of epistasis in GWAS studies, as well as the missing heritability problem.
Brief introduction into the problem of identifying causal variants, from association signals detected in GWAS.
